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🏥 | Sanyutei Arama-san, after being sentenced to life expectancy for another six months ... talks about liver transplantation and recovery


Photo Sanyutei Arama-san (provided by himself)

Sanyutei Arama-san, after being sentenced to life expectancy for another six months ... talks about everything from liver transplantation to recovery

 
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Above all, it is said that immunosuppressants should be taken twice a day, every 1 hours, and continued to be taken for the rest of their lives.
 

[Monologue pleasant "sick people"] Sanyutei Arama (Rakugoka / 44 years old) = Congenital biliary atresia / liver failure ◇◇… → Continue reading

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Immunosuppression

ImmunosuppressionWhat is (Immunosuppression)?Immune systemIt is a word that means a decrease in the activation ability and effectiveness of.Some parts of the immune system have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as a side effect of treating other diseases.[1][2].

In general, intentional immunosuppression isOrgan transplantationOf the body at the timeRejectionIs carried out to deter[3].. Furthermore,Bone marrow transplantationAfterGraft-versus-host diseaseTreatment andSystemic lupus erythematosus,Rheumatoid arthritis,Sjogren's syndrome,Crohn's diseaseSuch asAutoimmune diseaseIt is also used for the treatment of.Generally performed with drugs, but surgery (Splenectomy) AndPlasmapheresis, Radiation may be used.Patients receiving immunosuppressive therapy and other reasons (chemical treatment,HIV) For patients with weakened immune systemImmunodeficiencyCalled state[4].

Intentional immunosuppression

Administration of immunosuppressive drugs is the primary method for deliberately inducing immunosuppression.In optimal situations, immunosuppressive drugs primarily target overactive components of the immune system.[5]..Patients in remission of cancer who need immunosuppressive drugs are not likely to relapse[6].Radiation therapyHas also been used in its history to reduce immunity[7]..Brigham and Women's HospitalJoseph MurrayIn 1990, he studied immunosuppression.Nobel Prize in Physiology or MedicineHas been awarded[8].

Immunosuppressive drugs can cause immunodeficiency,Opportunistic infectionsIncrease the morbidity ofImmune cancer monitoring functionOr lower[9]..Immunosuppressive drugsAutoimmune diseaseIt may be prescribed when a normal immune response cannot be expected due to such reasons.[10].

Steroids are one of the first immunosuppressive drugs discovered, but early compounds had side effects and their use was restricted.Fewer side effectsAzathioprineWas discovered in 1960, and cyclosporine (in combination with azathioprine) was discovered in 1980, leading to poorly compatible pairs of donors and recipients.Organ transplantationHas been greatly expanded ...Heart transplantHas become widely applied to[3]..After organ transplantation, between the donor and the recipientHuman leukocyte antigenDue to the difference, the body almost always rejects new organs.As a result, the immune system recognizes the new tissue as a "foreign body" and attacks it with white blood cells to try to remove it, killing the donated tissue.Immunosuppressive drugs are given to prevent rejection, but they are more susceptible to infections and malignant tumors during treatment.[11][12][13].

Unintentional immunosuppression

Unintentional immunosuppression, for example,Capillary diastolic ataxia,, many kindscancer,Human immunodeficiency virusSpecific such as (HIV)Chronic infectionIt may happen in such cases.Unintentional immunosuppression is caused by bacteria, viruses, etc.PathogenUndesirable effect of increasing sensitivity toImmunodeficiency)[1].

Immunodeficiency is a lotImmunosuppressive drugIt is also a potential side effect of.In this sense, the general scope of the term immunosuppression includes both beneficial and potentially detrimental effects that reduce the function of the immune system.[14].

B cellsInsufficiencyT cellsInsufficiency is a congenital or acquired immune disorder that can result in immunodeficiency.[15](As an example of T-cell immunodeficiency(English edition)Can be mentioned[16]).

footnote

  1. ^ a b "Immunodeficiency disorders: MedlinePlus Medical Encyclopedia" (English). medlineplus.gov. 2017/5/6Browse.
  2. ^ "NCI Dictionary of Cancer Terms" (English). National Cancer Institute (September 2011, 2). 2017/5/6Browse.
  3. ^ a b Immunosuppression: Overview, History, Drugs. (2017-01-06). http://emedicine.medscape.com/article/432316-overview. 
  4. ^ "NCI Dictionary of Cancer Terms" (English). National Cancer Institute (September 2011, 2). 2019/11/28Browse.
  5. ^ Wiseman, Alexander C. (2016-02-05). “Immunosuppressive Medications”. Clinical Journal of the American Society of Nephrology 11 (2): 332–343. two:10.2215 / CJN.08570814. ISSN 1555-9041. PMC 4741049. PMID 26170177. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741049/. 
  6. ^ Shelton, Edward; Laharie, David; Scott, Frank I .; Mamtani, Ronac; Lewis, James D .; Colombel, Jean-Frederic; Ananthakrishnan, Ashwin N. (July 2016). “Cancer Recurrence Following Immune-Suppressive Therapies in Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis”. Gastroenterology 151 (1): 97–109.e4. two:10.1053 / j.gastro.2016.03.037. PMC 4925196. PMID 27039969. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925196/. 
  7. ^ Ladwig, Gail B .; Ackley, Betty J .; Makic, Mary Beth Flynn (2016-03-15). Mosby's Guide to Nursing Diagnosis --E-Book. Elsevier Health Sciences. P. 28. ISBN 9780323390279. https://books.google.com/books?id=w5bBCwAAQBAJ&q=radiation+therapy+decreases+strength+of+immune+system&pg=PA28 
  8. ^ "Joseph E. Murray --Facts". www.nobelprize.org. 2017/5/12Browse.
  9. ^ "Immunosuppression" (English). National Cancer Institute (September 2015, 4). 2017/7/13Browse.
  10. ^ Chandrashekara, S. (2012). “The treatment strategies of autoimmune disease may need a different approach from conventional protocol: A review”. Indian Journal of Pharmacology 44 (6): 665–671. two:10.4103/0253-7613.103235. ISSN 0253-7613. PMC 3523489. PMID 23248391. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523489/. 
  11. ^ "Transplant rejection: MedlinePlus Medical Encyclopedia" (English). medlineplus.gov. 2017/7/14Browse.
  12. ^ Immunology of Transplant Rejection: Overview, History, Types of Grafts. (2017-03-09). http://emedicine.medscape.com/article/432209-overview#a7. 
  13. ^ Charles A Janeway, Jr; Travers, Paul; Walport, Mark; Shlomchik, Mark J. (2001). Responses to alloantigens and transplant rejection. https://www.ncbi.nlm.nih.gov/books/NBK27163/. 
  14. ^ Lallana, Enrico C; Fadul, Camilo E (2011). “Toxicities of Immunosuppressive Treatment of Autoimmune Neurologic Diseases”. Current Neuropharmacology 9 (3): 468–477. two:10.2174/157015911796557939. ISSN 1570-159X. PMC 3151601. PMID 22379461. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151601/. 
  15. ^ "Immunodeficiency (Primary and Secondary). Information." (English). patient.info. 2017/7/13Browse.
  16. ^ Disorders, National Organization for Rare (2003). NORD Guide to Rare DisordersLippincott Williams & Wilkins. P. 408. ISBN 9780781730631. https://books.google.com/books?id=99YPDvFWBB0C&q=Nezelof+syndrome&pg=PA408 2017/6/2Browse. 

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